One of the compounds that can be used as an antidiabetic is flavonoids. This compound can reduce blood sugar levels by its role as an inhibitor of α-amylase enzyme. Where it can convert disaccharides into glucose. In addition, flavonoids can also inhibit glucose absorption in the small intestine so that they can function as antidiabetics. This flavonoid content can be found in purple kencana leaves.
“The biggest obstacle to flavonoid compounds obtained from purple gold is the degradation that occurs before it reaches the target organs. “This can be overcome with a targeted drug delivery system using the microencapsulation method,” said Rachmadi Azhar Fathoni, one of the team members.
In an effort to develop a targeted drug delivery system through flavonoid microencapsulation, five students consisting of: Rachmadi Azhar Fathoni (Chemistry), Moh Adrian Barra (Chemistry), Layla Az-Zahra (Chemistry), Voleta Alda Lathifah (Physics) and Danang Wahyu Pamungkas (Actuarial Science) Brawijaya University with supervisor Anna Safitri, S.Sc. , M.Sc., Ph.D. collaborated to develop dextrin and casein-based flavonoid microencapsulation as antidiabetic.
The mixture of microencapsulation coating materials has the potential to obtain microcapsules with good and stable adhesion. Moreover, these microcapsules can protect flavonoid compounds until they reach the target organs. So flavonoids can be released in the target organ, namely the small intestine.
This research received funding from the Student Creativity Program in the field of Exact Research. These five students united their thoughts and energy to fight to enter the upcoming National Student Science Week (PIMNAS) XXXVI 2023.
“This research is actually our first step as students to participate in realizing the Tridharma of Higher Education. “Through this research, we hope that it can be developed further so that what we do does not stop here, but can be produced on a massive scale so that we can provide alternative herbal medicine therapy to help diabetes survivors,” said Rachmadi as a hope representing his team. . [tim/sitirahma/ UB PR/ Trans. Iir]
